It’s never too LATE: A new look at local average treatment effects with or without defiers

Promotion of cardiovascular health at three stages of life: never too soon, never too late.

Cardiovascular disease is the leading cause of death worldwide, with an especially devastating impact in low-to-medium income countries. Cardiovascular disease has been elevated to this position by a combination of factors that include urbanization and its attendant effects, such as obesity, a sedentary lifestyle, changes in dietary habits, and smoking. Given the enormous extent of the problem ...

Never Too Early, Never Too Late: Effects of Search Timing on Product Innovation

A significant stream of research has emerged to study search (i.e., problem-solving) in organizations, and several insights have been discovered through this work. One is that firms search close to their current knowledge-bases (Nelson and Winter, 1982), and that searching further than that is rare and risky (Katila, 2002). Another is that successful search often combines knowledge that is know...

Ondine's curse--never too late.

a normal life span. It has recently been shown that CCHS confers risk for adverse neurocognitive outcome [3]. Visuoperceptual reasoning and clerical/ visuographic speed appear particularly vulnerable. In this issue of IMAJ, Cohen-Cymberknoh and colleagues [4] present an interesting and unusual case of a 12 year old girl with late-onset CCHS that was suspected and diagnosed only after she failed...

It's never too late to quit smoking.

Smoking Cessation: It Is Never Too Late

Public health and smoking are old enemies because smoking is among the 10 leading causes of ill health on a global scale and is also possible to prevent, as repeatedly reported (1). In both developed and developing countries, smoking takes its heavy toll of lives every year, both directly and indirectly, through exposure to passively inhaled tobacco smoke (2) or via feto-placental effects. Much...